Our latest publication!

Gordon, N.K. & R. Gordon (2016). The organelle of differentiation in embryos: the cell state splitter [invited review]. Theoretical Biology and Medical Modelling 13(Special issue: Biophysical Models of Cell Behavior, Guest Editor: Jack A. Tuszynski), #11. (The publication is open source, no fee to read.)

Abstract

The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending a microtubule mat. The microtubules and microfilament ring are in mechanical opposition as in a tensegrity structure. The cell state splitter is bistable, perturbations causing it to contract or expand radially. The intermediate filament ring provides metastability against small perturbations. Once this snap-through organelle is triggered, it initiates signal transduction to the nucleus, which changes gene expression in one of two readied manners, causing its cell to undergo a step of determination and subsequent differentiation. The cell state splitter also triggers the cell state splitters of adjacent cells to respond, resulting in a differentiation wave. Embryogenesis may be represented then as a bifurcating differentiation tree, each edge representing one cell type. In combination with the differentiation waves they propagate, cell state splitters explain the spatiotemporal course of differentiation in the developing embryo. This review is excerpted from and elaborates on “Embryogenesis Explained” (World Scientific Publishing, Singapore, 2016).

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About tumbleweedstumbling

I have three blogs, embryogenesis explained, tumbleweed tumbling AND fulltimetumbleweed. I am a scientist, and my husband and I have written a book which will be published soon by World Scientific Publishing called Embryogensis Explained. Full time tumbleweed was my first blog which I worked on during five years of living full time in a travel trailer. I have now retired that blog in favour of Tumbleweeds Tumbling since we bought a stick house in April 2015 and are no longer full-time. I have a blended family of five sons and one daughter, all grown up now. I am (step)grandmother to nine boys and one girl. My husband and I have two dogs and a cat. We spend summers in Manitoba, Canada, in a 480 square foot house on a half acre of land in the tiny town of Alonsa. We spend winters in the USA. My husband is retired and being a US citizen, he does volunteer work in winters for Gulf Specimen Marine Lab in Panacea Florida as their emeritus. I retired in Sept 2013 and so far I am loving it.

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